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Wednesday, February 9, 2011

Postdoctoral Position in Computational Biology -Multi-objective optimization for modeling developmental gene regulatory networks

Description: The project is financed by the NWO research programme Interdisciplinary Challenges for Complexity Science (Complexity-Net). The project is a collaboration with the research groups from Dr J. Jaeger (Centre for Genomic Regulation, Barcelona, Spain) and Dr F. Alves (Center for Developmental Biology, Lisbon, Portugal). The candidate is expected to collaborate extensively with system biologists and molecular developmental biologists.In this project, we propose to compare distinct network modeling formalisms applied to the study of real-world developmental gene regulatory networks. An important challenge is the determination of model parameters. Even models of moderately sized networks contain a large number of (unknown) parameters. We propose to use multi-objective optimization for the network inference and estimation of unknown model parameters. Models will be optimized both with regard to their ability to fit the data, as well as their robustness towards molecular fluctuations and changes in parameter values. In this part of the project we will use qualitative and quantitative spatial gene expression data from the sea anemone Nematostella vectensis. We want to test systematically under which circumstances each formalism is best able to reproduce the observed expression patterns and which one is the most suited for prediction of network topology and perturbed gene expression, and is able to reproduce the robustness of pattern forming gene regulatory networks..

Requirements

Candidates should have a master’s degree (or equivalent) in scientific computing or computational science, (computational) physics, (computational) chemistry or a comparable expertise.  Candidates are expected to have expertise in modeling and scientific programming and an active interest in life science applications. The Candidate should be able to work in an international research team. A strong research record, evidenced by a PhD thesis and papers published in peer-reviewed journals is needed. Fluency in oral and written English is required. Motivation to travel to a different country and integrate efficiently in a new research team is fundamental.
Contact: Dr J. A. Kaandorp, Informatics Institute, University of Amsterdam, Kruislaan 403, 1098 SJ, Amsterdam, The Netherlands; +31 20 525 7539 +31 20 525 7539 
Email:  J.A.Kaandorp@uva.nl.

Appointment

This full-time appointment will be on a temporary basis for a maximum period of two years. The salary is in accordance with the university regulations for academic personnel, and will range from €2,379 before tax, up to a maximum of €3,755 per month (scale 10). The holiday allowance is 8% of the annual gross income. Furthermore, there will be an annual bonus of 8.3% of the annual gross income. The Collective Employment Agreement of the Dutch Universities applies.

 Application:

Applications should include a letter of motivation, pdfs of most relevant publications and a Curriculum Vitae. Please include the names and contact information of two references. Applications should be sent by e-mail to Mrs J.C. Knaap-Cabi at application-science@uva.nl.The application period will remain open until the position is filled; however, review of applications will commence on 13 February 2011
Deadline: 13 February 2011
Links: For more details click here
University of Amsterdam,Netherlands,deadline-13-02-2011,Postdoc,Biology

Wednesday, February 2, 2011

PhD scholarship @ DTU, Denmark in development of functionally graded materials for thermoelectric devices


Description: The Fuel Cells and Solid State Chemistry Division at Risø DTU is seeking a Ph.D. student to develop graded thermoelectric materials with optimized properties over a broad temperature range for use in conversion of heat into electricity.This will take place at the international front line in collaboration between Risø DTU and four leading laboratories in Denmark, Japan and the US, while industry participation ensures strong links to both technology providers and end-users.A major challenge in thermoelectric materials development is to combine a number of materials belonging to different families of materials together in order to improve the conversion efficiency and to expand the working temperature range of the thermoelectric device. The project is focussed on the construction and optimization of p- and n-type segments over a broad temperature range by graded materials. This will be done in order to improve the so-called compatibility factor between the materials in each leg. The materials are chosen among the best of state-of-the-art materials and the novel developed thermoelectric oxides.
Requirements: Candidates should have -Master’s degree in chemistry, physics, materials science or similar
  • Knowledge in synthesis of inorganic materials preferably oxides
  • Prior knowledge in the area of thermoelectricity is beneficial
  • Experience with experimental methods for materials characterization
  • Ability to work independently, to plan and carry out complicated tasks, and to be a part of a large, dynamical group
  • Good communication skills in English, both written and spoken
Application Please apply online on www.dtu.dk/vacancy and open the link “apply for this job online”, fill in the application form and attach the following documents;
a) A letter motivating the application (cover letter)
b) Curriculum vitae
c) Grade transcripts and BSc/MSc diploma
d) Conversion of grade averages to Danish grades (see guidelines and excel spreadsheet for the conversion 
here).
Candidates may apply prior to obtaining their master’s degree, but cannot begin before having received it.
All interested candidates irrespective of age, gender, race, inability, religion or ethnic background are encouraged to apply.
Further information
Please contact Nini Pryds +45 46 77 57 52 +45 46 77 57 52       or Ngo Van Nong, +45 51 42 30 23 +45 51 42 30 23       for further information.

Links: For more details click here .Additional information about Risø DTU and the Fuel Cells and Solid State Chemistry Division can be found on risoe.dtu.dk.
Deadline: 15 February 2011

PhD scholarship @ DTU-Denmark in development and processing of n-type oxide thermoelectric materials


Description: The DTU is seeking a PhD student to develop and process new types of oxide thermoelectric materials for use in conversion of heat into electricity.You will be part of a large project which aim to develop and demonstrate high-temperature efficient thermoelectric oxide modules integrated in a converter system.This will take place at the international front line in collaboration between Risø DTU and four leading laboratories in Denmark, Japan and the US, while industry participation ensures strong links to both technology providers and end-users.
Requirements: Candidates should have
  • Master’s degree in chemistry, physics, materials science or similar
  • Knowledge in synthesis of inorganic materials preferably oxides
  • Prior knowledge in the area of thermoelectricity is beneficial
  • Experience with experimental methods for materials processing and characterization
  • Ability to work independently, to plan and carry out complicated tasks, and to be a part of a large, dynamical group
  • Good communication skills in English, both written and spoken
We offer
We offer an exciting and challenging job in an international environment.
Good possibilities for professional and personal growth.
A family friendly organisation with flexible working hours.

Application: Please apply online on www.dtu.dk/vacancy and open the link “apply for this job online”, fill in the application form and attach the following documents;
a) A letter motivating the application (cover letter)
b) Curriculum vitae
c) Grade transcripts and BSc/MSc diploma
d) Conversion of grade averages to Danish grades (see guidelines and excel spreadsheet for the conversion
here).
Candidates may apply prior to obtaining their master’s degree, but cannot begin before having received it.
All interested candidates irrespective of age, gender, race, inability, religion or ethnic background are encouraged to apply.
Contact:
Please contact Nini Pryds,  +45 46 77 57 52 +45 46 77 57 52       Ngo Van Nong, +45 51 42 30 23 +45 51 42 30 23     

Link: For more details click here. Additional information about Risø DTU and the Fuel Cells and Solid State Chemistry Division can be found on risoe.dtu.dk.
Deadline: 15 february 2011


Tuesday, February 1, 2011

Saltire Scholarships @ Scotland


Description: Scotland’s Saltire Scholarships (SSS) is a substantial programme of scholarships, offered on a matched funding basis between the Government and Scottish Higher Education Institutions. The scheme offers up to 200 awards, each worth £2000, towards the tuition fees of a one year Masters course at any of Scotland’s higher education institutions.The scholarships are designed to support the promotion of Scotland as a learning nation and a science nation and are therefore targeted at the priority sectors of creative industries, life sciences, technology, financial services and renewable and clean energy (find out what study options are available). These are available across key priority countries:
  • Canada
  • China
  • India
  • United States of America
The scholarships are available to students as part of a wider strategy to promote Scotland as a study destination and showcase Scotland’s higher education offering in international markets.
This is the third year of the programme which was launched in January 2009, nearly 400 scholarships have been awarded to date.
Deadline: The closing date for 2011/12 awards is 17 June 2011.
Link: For more details click here

Post doctoral position@ University of Copenhagen in miRNA biology

Description: The University of Copenhagen, is recruiting a post doctoral researcher for a 2-year project to work on mechanisms of microRNA (miRNA) action in the newly established research group of Peter Brodersen. The group uses the plant Arabidopsis thaliana to study mechanisms employed by miRNAs to regulate gene expression. The successful candidate will investigate the association of the silencing machinery with membrane compartments using primarily biochemical and genetic approaches. A major goal of the project is to identify and characterize novel factors required for membrane recruitment of the silencing machinery.We are looking for a highly motivated individual with a Ph.D. degree in molecular biology or equivalent. Experience with protein purification in addition to standard molecular biological skills will be considered an advantage, but is not a formal requirement. The applicant must be fluent in written as well as spoken English. The position is open to all applicants regardless of nationality, and will be funded by a grant from the Novo Nordisk Foundation.
Applications: Applications should be sent as a single pdf file to Job15@bio.ku.dk marked “211-0055/11-5550″ no later than February 14, 2011 and must contain the following sections: A 1-page letter explaining the applicant´s background and reasons for applying, a 1-page curriculum vitae, a list of peer-reviewed publications (may include papers under review), master diploma including grades, Ph.D. diploma including any evaluation if applicable. Letters of recommendation may be included at the end of the application. In addition, a signed hardcopy of the application must be posted to “Peter Brodersen”, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
Contact: Associate Professor Peter Brodersen, e-mail pbrodersen@bio.ku.dk
Link: http://www.biocenter.ku.dk/


Postdoc position in Disease Systems Biology @ Department of Disease Systems Biology – Computational analysis of data from embryonal tumours


Description: The Department of Disease Systems Biology headed by Prof. Søren Brunak works on disease-related integrative biology, in close contact with the other research groups at the Center, and focuses on a number of projects, including kinome-wide understanding of signal transduction networks; impact of human variation on signal transduction (germline and somatic); network association between diseases, genes, proteins and chemical compounds and disease-related text mining of electronic patient records, biobank data and biomedical literature.The ideal candidate should be able to conduct independent and creative research within systems biology, demonstrate scientific productivity, and show good interpersonal and communication skills. The postdoctoral fellow will be involved in the ongoing research projects in the department and will play a key role in the department´s obligation in the EU FP7 research project, ASSET: Analyzing and Striking the Sensitivities of Embryonal Tumours. ASSET operates a systems biology-driven discovery and validation engine to achieve the following objectives:
  • network analysis of time-resolved phosphoproteomics data from embryonic tumor tyrosine kinase activated cell lines in collaboration with the Department of Proteomics at CPR,
  • the combined analysis of genomic mutations, transcriptome, miRNA expression and dynamic proteome changes,
  • systematic perturbations to probe and refine these networks,
  • Implementation of a virtuous cycle of model making and validation in relevant biological model systems (cell culture models and preclinical mouse models) and clinical samples.
Qualifications:
  • The candidate is required to have a PhD or equivalent degree in natural or medical science.
  • Excellent scientific track record.
  • Prior experience in computational biology, data curation and data interpretation is highly desired.
  • Knowledge in genetics and biology, cell signaling, cancer systems biology and/or embryonal diseases would be considered a distinct advantage.
  • Good communication skills, both oral and written.
  • An analytical attitude of devising innovative scientific or technical solutions.
  • Demonstrate enthusiasm, motivation, flexibility and confidence.
Contact: For Professor Søren Brunak (soren.brunak@cpr.ku.dk) Your application Should include a CV as well as names and contact details of two referees must be sent to the Novo Nordisk Foundation Center for Protein Research before 10 February 2011by e-mail to jobs@cpr.ku.dk
Deadline: 10 February,2011.


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