Postdoc position in Disease Systems Biology @ Department of Disease Systems Biology – Computational analysis of data from embryonal tumours

Description: The Department of Disease Systems Biology headed by Prof. Søren Brunak works on disease-related integrative biology, in close contact with the other research groups at the Center, and focuses on a number of projects, including kinome-wide understanding of signal transduction networks; impact of human variation on signal transduction (germline and somatic); network association between diseases, genes, proteins and chemical compounds and disease-related text mining of electronic patient records, biobank data and biomedical literature.The ideal candidate should be able to conduct independent and creative research within systems biology, demonstrate scientific productivity, and show good interpersonal and communication skills. The postdoctoral fellow will be involved in the ongoing research projects in the department and will play a key role in the department´s obligation in the EU FP7 research project, ASSET: Analyzing and Striking the Sensitivities of Embryonal Tumours. ASSET operates a systems biology-driven discovery and validation engine to achieve the following objectives:

• network analysis of time-resolved phosphoproteomics data from embryonic tumor tyrosine kinase activated cell lines in collaboration with the Department of Proteomics at CPR,
• the combined analysis of genomic mutations, transcriptome, miRNA expression and dynamic proteome changes,
• systematic perturbations to probe and refine these networks,
• Implementation of a virtuous cycle of model making and validation in relevant biological model systems (cell culture models and preclinical mouse models) and clinical samples.

Qualifications:

• The candidate is required to have a PhD or equivalent degree in natural or medical science.
• Excellent scientific track record.
• Prior experience in computational biology, data curation and data interpretation is highly desired.
• Knowledge in genetics and biology, cell signaling, cancer systems biology and/or embryonal diseases would be considered a distinct advantage.
• Good communication skills, both oral and written.
• An analytical attitude of devising innovative scientific or technical solutions.
• Demonstrate enthusiasm, motivation, flexibility and confidence.

Contact: For Professor Søren Brunak (soren.brunak@cpr.ku.dk) Your application Should include a CV as well as names and contact details of two referees must be sent to the Novo Nordisk Foundation Center for Protein Research before 10 February 2011by e-mail to jobs@cpr.ku.dk
Deadline: 10 February,2011.